Edited by Michael Garoutte, this group of POGIL activities is the result of a collaborative project whose primary goal was to create guided inquiry laboratory experiences with relevant connections between the experiments and broader topics of student interest. Eleven faculty, experienced in using guided inquiry in class, lab, or both, and representing a wide range of institutions, developed and tested the activities with their classes. Collaborators include Ehren Bucholtz, Stacey Fiddler, Michael Garoutte, Tim Herzog, Ashley Mahoney, Rick Moog, Marty Perry, Craig Teague, Mary Twist van Opstal, Gail Webster, and Rob Whitnell. Institutions at which the activities were tested include Bethel University (MN), Cornell College (IA), Franklin & Marshall College (PN), Guilford College (NC), Harper College (IL), Missouri Southern State University (MO), Portland Community College (OR), University of Health Sciences and Pharmacy (MO), and Weber State University (UT).