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Advanced Biology: Differential Gene Expression: Enhancers and Transcription Factors

Advanced Biology: Differential Gene Expression: Enhancers and Transcription Factors

Author(s): The POGIL Project , Megan Morgan Hoffman

Edition: 1

Copyright: 2025

Pages: 18

Edition: 1

Copyright: 2025

Pages: 18

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This activity is written for upper-level biology courses and aims to acquaint students with the function of transcription factors, especially in determining the fate of cells. Students who complete this activity will explain and illustrate how cells with the same DNA produce different proteins and predict gene activity based on relevant gene regulation factors. Process skill: forming an argument or reaching a conclusion supported with evidence. 

POGIL eBooks are delivered through VitalSource – the world’s leading platform for accessing, consuming, and engaging with digital textbooks and course materials.  While designed to be used anywhere on a myriad of devices, users are able to print two watermarked pages at a time when in a pinch.

POGIL eBooks are delivered through VitalSource – the world’s leading platform for accessing, consuming, and engaging with digital textbooks and course materials.  While designed to be used anywhere on a myriad of devices, users are able to print two watermarked pages at a time when in a pinch.

The POGIL Project

Kendall Hunt is excited to partner with The POGIL Project to publish materials in a variety of disciplines that are designed for use in active learning, student-centered classrooms.

POGIL is an acronym for Process Oriented Guided Inquiry Learning. Because POGIL is a student-centered instructional approach, in a typical POGIL classroom or laboratory, students work in small teams with the instructor acting as a facilitator. The student teams use specially designed activities that generally follow a learning cycle paradigm. These activities are designed to have three key characteristics:

  • They are designed for use with self-managed teams that employ the instructor as a facilitator of learning rather than a source of information.
  • They guide students through an exploration to construct understanding.
  • They use discipline content to facilitate the development of important process skills, including higher-level thinking and the ability to learn and to apply knowledge in new contexts. 

For more information, please visit www.pogil.org

Megan Morgan Hoffman

Megan Morgan Hoffman earned her B.A. in biology from Dartmouth College in 1983 and her Ph.D. in Biological Sciences (neural science) from Washington University in St. Louis in 1990. She completed a post-doctoral fellowship at Bryn Mawr College in 1994. Dr. Hoffman is Professor of Biology at Berea College, where for over 30 years she has taught introductory biology, neurobiology, and developmental biology. She holds the Harold R. Adams Chair in Biological Sciences, received the Outstanding College/University Teacher Award from the Kentucky Academy of Science in 2013 and the Berea College Seabury Award for Excellence in Teaching in 2018. Dr. Hoffman has been active in The POGIL Project since 2006, serving as a workshop facilitator, an author and author coach, and a member of numerous committees and project teams. 

This activity is written for upper-level biology courses and aims to acquaint students with the function of transcription factors, especially in determining the fate of cells. Students who complete this activity will explain and illustrate how cells with the same DNA produce different proteins and predict gene activity based on relevant gene regulation factors. Process skill: forming an argument or reaching a conclusion supported with evidence. 

POGIL eBooks are delivered through VitalSource – the world’s leading platform for accessing, consuming, and engaging with digital textbooks and course materials.  While designed to be used anywhere on a myriad of devices, users are able to print two watermarked pages at a time when in a pinch.

POGIL eBooks are delivered through VitalSource – the world’s leading platform for accessing, consuming, and engaging with digital textbooks and course materials.  While designed to be used anywhere on a myriad of devices, users are able to print two watermarked pages at a time when in a pinch.

The POGIL Project
The POGIL Project

Kendall Hunt is excited to partner with The POGIL Project to publish materials in a variety of disciplines that are designed for use in active learning, student-centered classrooms.

POGIL is an acronym for Process Oriented Guided Inquiry Learning. Because POGIL is a student-centered instructional approach, in a typical POGIL classroom or laboratory, students work in small teams with the instructor acting as a facilitator. The student teams use specially designed activities that generally follow a learning cycle paradigm. These activities are designed to have three key characteristics:

  • They are designed for use with self-managed teams that employ the instructor as a facilitator of learning rather than a source of information.
  • They guide students through an exploration to construct understanding.
  • They use discipline content to facilitate the development of important process skills, including higher-level thinking and the ability to learn and to apply knowledge in new contexts. 

For more information, please visit www.pogil.org

Megan Morgan Hoffman
Megan Morgan Hoffman

Megan Morgan Hoffman earned her B.A. in biology from Dartmouth College in 1983 and her Ph.D. in Biological Sciences (neural science) from Washington University in St. Louis in 1990. She completed a post-doctoral fellowship at Bryn Mawr College in 1994. Dr. Hoffman is Professor of Biology at Berea College, where for over 30 years she has taught introductory biology, neurobiology, and developmental biology. She holds the Harold R. Adams Chair in Biological Sciences, received the Outstanding College/University Teacher Award from the Kentucky Academy of Science in 2013 and the Berea College Seabury Award for Excellence in Teaching in 2018. Dr. Hoffman has been active in The POGIL Project since 2006, serving as a workshop facilitator, an author and author coach, and a member of numerous committees and project teams.