Integrative Pathophysiology: Cellular Insights and Nutritional Considerations
Edition: 1
Copyright: 2025
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This multidisciplinary textbook bridges the fields of cell biology, physiology, and pathology to explore the biological foundations of common diseases closely linked to nutrition. Rather than serving as a comprehensive pathophysiology resource, the book focuses on a curated selection of conditions rooted in nutritional imbalances, offering a focused and integrated approach to nutritional strategies that support the management and improvement of these diseases.
Designed for students and professionals in health sciences, nutrition, and biomedical fields, the text combines scientific rigor with clinical relevance. Each chapter examines the cellular and physiological mechanisms underlying specific conditions, while also presenting evidence-based nutritional strategies for prevention and management.
Each chapter examines cellular and physiological mechanisms underlying specific conditions, presents evidence-based nutritional strategies, and includes case studies with biochemical panels, MCAT-style questions, evolutionary and historical perspectives, and universal excellence boxes to raise awareness about today’s unresolved global challenges.
CHAPTER 1 Bridging Cell Biology, Disease and Nutrition
CHAPTER 2 Gastrointestinal Physiology, Pathology, and Nutritional Considerations
CHAPTER 3 Glucose Metabolism, Diabetes and Nutritional Considerations
CHAPTER 4 Energy Balance, Obesity, Malnutrition and Nutritional Considerations
CHAPTER 5 Cardiovascular Physiology, Pathology and Nutritional Considerations
CHAPTER 6 Renal System
CHAPTER 7 Erythrocyte Physiology, Anemia and Nutritional Considerations
CHAPTER 8 Bone Physiology, Osteoporosis, Rickets and Nutritional Considerations
CHAPTER 9 Neoplasia and Nutritional Considerations
Dr. Gioia Polidori has a broad background in various fields of biology. Her academic journey began at Università Roma Tre, in Rome, Italy, where she completed the first of three master’s degrees in molecular biology. She then went on to complete additional master’s degrees in clinical and applied nutrition and dietetics as well as in medical molecular genetics. She completed her PhD work at the University of Aberdeen, Scotland, where she used mouse embryonic stem cells as a model system to study the developmental origin of adipose tissue depots to ultimately elucidate the nutritional underpinnings of type II diabetes. During her postdoctoral work at the University of California, Los Angeles, Dr. Polidori investigated the developmental origin of cardiomyocytes to explore the potential of human embryonic stem cells in developing novel treatments for myocardial infarction. Since 2015, she has been a faculty member at the University of Southern California, where she is currently an Associate Professor of Teaching and Director of the Undergraduate Studies for the Human Biology program. Here, Dr. Polidori uses a multidisciplinary approach that draws on her diverse and unique scientific background to teach a variety of courses, including Nutrition and Disease, Nutrition for Life, Genetics and Disease, and Evolutionary Medicine. A native of Rome, Dr. Polidori grew up in a multicultural environment and began traveling at the young age of three, eventually being drawn to visit around 60 countries. Along the way, she developed an appreciation for diverse cultures and perspectives, which fostered a deeper understanding of health issues, an awareness that informs her teaching and fuels her commitment to raising awareness about today’s unresolved challenges through education.
This multidisciplinary textbook bridges the fields of cell biology, physiology, and pathology to explore the biological foundations of common diseases closely linked to nutrition. Rather than serving as a comprehensive pathophysiology resource, the book focuses on a curated selection of conditions rooted in nutritional imbalances, offering a focused and integrated approach to nutritional strategies that support the management and improvement of these diseases.
Designed for students and professionals in health sciences, nutrition, and biomedical fields, the text combines scientific rigor with clinical relevance. Each chapter examines the cellular and physiological mechanisms underlying specific conditions, while also presenting evidence-based nutritional strategies for prevention and management.
Each chapter examines cellular and physiological mechanisms underlying specific conditions, presents evidence-based nutritional strategies, and includes case studies with biochemical panels, MCAT-style questions, evolutionary and historical perspectives, and universal excellence boxes to raise awareness about today’s unresolved global challenges.
CHAPTER 1 Bridging Cell Biology, Disease and Nutrition
CHAPTER 2 Gastrointestinal Physiology, Pathology, and Nutritional Considerations
CHAPTER 3 Glucose Metabolism, Diabetes and Nutritional Considerations
CHAPTER 4 Energy Balance, Obesity, Malnutrition and Nutritional Considerations
CHAPTER 5 Cardiovascular Physiology, Pathology and Nutritional Considerations
CHAPTER 6 Renal System
CHAPTER 7 Erythrocyte Physiology, Anemia and Nutritional Considerations
CHAPTER 8 Bone Physiology, Osteoporosis, Rickets and Nutritional Considerations
CHAPTER 9 Neoplasia and Nutritional Considerations
Dr. Gioia Polidori has a broad background in various fields of biology. Her academic journey began at Università Roma Tre, in Rome, Italy, where she completed the first of three master’s degrees in molecular biology. She then went on to complete additional master’s degrees in clinical and applied nutrition and dietetics as well as in medical molecular genetics. She completed her PhD work at the University of Aberdeen, Scotland, where she used mouse embryonic stem cells as a model system to study the developmental origin of adipose tissue depots to ultimately elucidate the nutritional underpinnings of type II diabetes. During her postdoctoral work at the University of California, Los Angeles, Dr. Polidori investigated the developmental origin of cardiomyocytes to explore the potential of human embryonic stem cells in developing novel treatments for myocardial infarction. Since 2015, she has been a faculty member at the University of Southern California, where she is currently an Associate Professor of Teaching and Director of the Undergraduate Studies for the Human Biology program. Here, Dr. Polidori uses a multidisciplinary approach that draws on her diverse and unique scientific background to teach a variety of courses, including Nutrition and Disease, Nutrition for Life, Genetics and Disease, and Evolutionary Medicine. A native of Rome, Dr. Polidori grew up in a multicultural environment and began traveling at the young age of three, eventually being drawn to visit around 60 countries. Along the way, she developed an appreciation for diverse cultures and perspectives, which fostered a deeper understanding of health issues, an awareness that informs her teaching and fuels her commitment to raising awareness about today’s unresolved challenges through education.